Steps for Prescribing Jakafi® (ruxolitinib)

IncyteCARES (Connecting to Access, Reimbursement, Education and Support) provides a single point of contact through a registered nurse to assist healthcare professionals in obtaining access to Jakafi for their eligible patients and to connect those patients with continuing support and resources.

Using a personalized approach, each IncyteCARES nurse works one-on-one with medical offices, patients, and caregivers throughout a patient’s involvement in the program. By providing individualized support from a single point of contact, IncyteCARES helps patients in moving their lives—and their treatment journey—forward.

Jakafi is available through a limited network of specialty mail-order pharmacies (SPs) and through select in-office pharmacies. Healthcare professionals, patients, and their caregivers can contact IncyteCARES nurses toll-free at 1-855-4-Jakafi (1-855-452-5234), Monday through Friday, 8 am–8 pm, ET.

Get started with IncyteCARES

Click To Download The IncyteCARES Enrollment Form

Take these 2 steps to connect your eligible patients with Jakafi

Step 1: Write A Prescription For Jakafi
Step 1:

Prescribe Jakafi

Write a prescription for Jakafi to an appropriate patient for an FDA-approved indication.

Step 2: Enroll Your Patient In IncyteCARES By Completing The Program Enrollment Form
Step 2:

Enroll your patient in IncyteCARES by completing the program enrollment form

Both you and the patient complete and sign the IncyteCARES enrollment form. Each page of the form needs to be printed, filled out, and then faxed to IncyteCARES at 1-855-525-7207.

The IncyteCARES enrollment form will serve as the patient's initial prescription for Jakafi. Be sure that the patient signs the enrollment form to receive access and reimbursement, plus Education and support services from IncyteCARES, if they would like to participate in these programs.

IncyteCARES Will Take The Next Steps To Process The Application

IncyteCARES will process the application and will:

  • Verify your patient's insurance benefits and any prior authorization requirements
  • Provide guidance on appealing an insurance denial, if needed
  • Connect eligible patients with assistance and resources
  • Send the prescription to a specialty pharmacy (SP) or an approved in-network or in-house pharmacy for shipment to your office or the patient’s home
  • Follow up on your patient’s progress with regularly scheduled phone calls

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Indications and Usage

Jakafi is indicated for treatment of polycythemia vera (PV) in adults who have had an inadequate response to or are intolerant of hydroxyurea.

Jakafi is indicated for treatment of intermediate or high-risk myelofibrosis (MF), including primary MF, post–polycythemia vera MF and post–essential thrombocythemia MF in adults.

Jakafi is also indicated for treatment of steroid-refractory acute graft-versus-host disease (GVHD) in adult and pediatric patients 12 years and older.

Important Safety Information

  • Treatment with Jakafi® (ruxolitinib) can cause thrombocytopenia, anemia and neutropenia, which are each dose‐related effects. Perform a pre‐treatment complete blood count (CBC) and monitor CBCs every 2 to 4 weeks until doses are stabilized, and then as clinically indicated
  • Manage thrombocytopenia by reducing the dose or temporarily interrupting Jakafi. Platelet transfusions may be necessary
  • Patients developing anemia may require blood transfusions and/or dose modifications of Jakafi
  • Severe neutropenia (ANC <0.5 × 109/L) was generally reversible by withholding Jakafi until recovery
  • Serious bacterial, mycobacterial, fungal and viral infections have occurred. Delay starting Jakafi until active serious infections have resolved. Observe patients receiving Jakafi for signs and symptoms of infection and manage promptly. Use active surveillance and prophylactic antibiotics according to clinical guidelines.
  • Tuberculosis (TB) infection has been reported. Observe patients taking Jakafi for signs and symptoms of active TB and manage promptly. Prior to initiating Jakafi, evaluate patients for TB risk factors and test those at higher risk for latent infection. Consult a physician with expertise in the treatment of TB before starting Jakafi in patients with evidence of active or latent TB. Continuation of Jakafi during treatment of active TB should be based on the overall risk‐benefit determination
  • Progressive multifocal leukoencephalopathy (PML) has occurred with Jakafi treatment. If PML is suspected, stop Jakafi and evaluate
  • Advise patients about early signs and symptoms of herpes zoster and to seek early treatment
  • Increases in hepatitis B viral load with or without associated elevations in alanine aminotransferase and aspartate aminotransferase have been reported in patients with chronic hepatitis B virus (HBV) infections. Monitor and treat patients with chronic HBV infection according to clinical guidelines
  • When discontinuing Jakafi, myeloproliferative neoplasm‐related symptoms may return within one week. After discontinuation, some patients with myelofibrosis have experienced fever, respiratory distress, hypotension, DIC, or multi‐organ failure. If any of these occur after discontinuation or while tapering Jakafi, evaluate and treat any intercurrent illness and consider restarting or increasing the dose of Jakafi. Instruct patients not to interrupt or discontinue Jakafi without consulting their physician. When discontinuing or interrupting Jakafi for reasons other than thrombocytopenia or neutropenia, consider gradual tapering rather than abrupt discontinuation
  • Non-melanoma skin cancers including basal cell, squamous cell, and Merkel cell carcinoma have occurred. Perform periodic skin examinations
  • Treatment with Jakafi has been associated with increases in total cholesterol, low-density lipoprotein cholesterol, and triglycerides. Assess lipid parameters 8-12 weeks after initiating Jakafi. Monitor and treat according to clinical guidelines for the management of hyperlipidemia
  • In myelofibrosis and polycythemia vera, the three most common nonhematologic adverse reactions (incidence >10%) were bruising, dizziness and headache. In acute graft-versus-host disease, the most common nonhematologic adverse reactions (incidence >50%) were infections and edema
  • Dose modifications may be required when administering Jakafi with strong CYP3A4 inhibitors or fluconazole or in patients with renal or hepatic impairment. Patients should be closely monitored and the dose titrated based on safety and efficacy
  • Use of Jakafi during pregnancy is not recommended and should only be used if the potential benefit justifies the potential risk to the fetus. Women taking Jakafi should not breastfeed during treatment and for two weeks after the final dose

Please see Full Prescribing Information for Jakafi.