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IncyteCARES for ZYNYZ is a program for residents
of the United States and Puerto Rico.

We're Here to Support You During Treatment With ZYNYZ® (retifanlimab-dlwr)

At IncyteCARES for ZYNYZ, our team can help you understand your insurance coverage, explore financial
assistance options, and provide as-needed support.

For Enrolled Patients, Our Team Will:

  • Call you to review your insurance coverage for ZYNYZ
  • Assess your eligibility for savings or financial assistance programs*
  • Explain additional support and resources available during your treatment

*Terms and conditions apply. Terms of these programs may change at any time.

Financial Assistance, Savings, and Support Options for ZYNYZ

Eligible patients can receive ZYNYZ for as little as $15, subject to certain limits

To qualify, you must:

  • Have commercial healthcare coverage. Patients insured under federal or state government healthcare programs—including Medicare Part B, Medicare Advantage, Medicaid, TRICARE, or any state medical or pharmaceutical assistance program—are not eligible. Patients without healthcare coverage are also not eligible
  • Be a resident of the United States or Puerto Rico
  • Have a valid prescription for ZYNYZ for an FDA-approved use

Maximum benefits per claim and per calendar year apply, as may other restrictions. Program benefit applies to medication cost only and does not cover any costs to administer the medication. Uninsured, cash-paying patients are not eligible. Not valid for patients insured through Medicare Part B,
Medicare Advantage, Medicaid, and TRICARE or any state medical or pharmaceutical assistance program. Offer valid only for an FDA-approved indication or recognized compendia use for ZYNYZ® (retifanlimab-dlwr). Please see full Patient Terms and Conditions or call IncyteCARES for ZYNYZ at 1-855-452-5234. Update effective as of December 1, 2023.

Maximum benefits per claim and per calendar year apply, as may other restrictions. Program benefit applies to medication cost only and does not cover any costs to administer the medication. Uninsured, cash-paying patients are not eligible. Not valid for patients insured through Medicare Part B,
Medicare Advantage, Medicaid, and TRICARE or any state medical or pharmaceutical assistance program. Offer valid only for an FDA-approved indication or recognized compendia use for ZYNYZ® (retifanlimab-dlwr). Please see full Patient Terms and Conditions or call IncyteCARES for ZYNYZ at 1-855-452-5234. Update effective as of December 1, 2023.

To enroll, you can either:

    1. Call IncyteCARES for ZYNYZ at 1-855-452-5234 , Monday through Friday, 8 AM–8 PM ET. A representative will ask a few questions. If you are eligible, we can enroll you in the Savings Program immediately so you can begin receiving ZYNYZ for as little as $15 out-of-pocket cost.
    2. Ask your Healthcare Professional to enroll you in the Savings Program.

Eligible patients can receive ZYNYZ free of charge

The IncyteCARES for ZYNYZ Patient Assistance Program (PAP) helps eligible patients who do not have medical insurance or who have trouble affording their out-of-pocket costs for ZYNYZ. The program provides free medication, but does not cover the cost to give you your infusion. No purchase contingencies or other obligations apply.

To qualify, you must:

  • Be confirmed as eligible for and enrolled in IncyteCARES for ZYNYZ
  • Be a resident of the United States or Puerto Rico
  • Have a valid prescription for ZYNYZ for an FDA-approved use
  • Meet one of these 3 criteria:

Uninsured

    1. You have no medical coverage and meet household income criteria

Underinsured

    1. text
    2. You have Medicare Part B and meet household income criteria and additional program requirements
    3. You have any other type of healthcare insurance (commercial, Medicaid, etc) but have exhausted or been denied coverage for ZYNYZ and meet household income criteria

To apply, you can either:

    1. Call IncyteCARES for ZYNYZ at 1-855-452-5234, Monday through Friday, 8 AM–8 PM ET. 

      To start, we’ll ask you a few questions to help determine your eligibility for this program.

      If you qualify, you must send us proof of your current household income. It can be one of the following: your most recent federal income tax return, your most recent W-2 earnings statement from your employer, or one month of your recent pay stubs. Once we review your income information, we’ll notify you if you are fully approved for the IncyteCARES Patient Assistance Program and can receive ZYNYZ for free.

    2. Ask your Healthcare Professional to submit an application form for you.

Terms and conditions apply. Terms of this program may change at any time.

Patient Authorization Form

Your Healthcare Professional or an IncyteCARES for ZYNYZ representative may ask you to fill out and submit the following form to complete your program application.

Patient Authorization for Enrolling in IncyteCARES for ZYNYZ

Submit your completed form by:

Fax to 1-855-525-7207 or Mail to IncyteCARES for ZYNYZ, PO Box 221798, Charlotte, NC 28222-1798

Patients may be eligible for help with medicine, treatment-related travel, and other costs.

If you do not qualify for our IncyteCARES for ZYNYZ Savings or Patient Assistance Programs, we may be able to provide information about other organizations or independent foundations that offer support. If you’re eligible, these independent organizations sometimes provide help with your medicine costs, transportation or lodging expenses related to treatment, or counseling services offered at reduced or no cost. Eligibility and availability of these programs are determined by the individual organizations.

To learn more:

Call IncyteCARES for ZYNYZ at 1-855-452-5234, Monday through Friday, 8 AM–8 PM ET.

Call Center Support icon

Questions?

Call IncyteCARES for ZYNYZ at 1-855-452-5234,

Monday through Friday, 8 AM–8 PM ET

INDICATIONS AND USAGE

ZYNYZ is a prescription medicine used to treat a type of skin cancer called Merkel cell carcinoma in adults. ZYNYZ may be used to treat your skin cancer when it has spread or returned.

It is not known if ZYNYZ is safe and effective in children.

ZYNYZ is approved based on tumor response and duration of response. There are ongoing studies to confirm the clinical benefit of ZYNYZ.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ZYNYZ?

ZYNYZ is a medicine that may treat a certain type of skin cancer by working with your immune system. ZYNYZ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

Lung problems: cough, shortness of breath, chest pain

Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; severe stomach-area (abdomen) pain or tenderness

Liver problems: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); bleeding or bruising more easily than normal

Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, loss of appetite

Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes

Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with ZYNYZ. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include:

  • chest pain, irregular heartbeat, shortness of breath, or swelling of ankles
  • confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
  • double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
  • persistent or severe muscle pain or weakness, muscle cramps
  • low red blood cells, bruising

Infusion reactions that can sometimes be severe. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, back or neck pain

Rejection of a transplanted organ. Your healthcare provider should tell you what signs and symptoms you should report and monitor you, depending on the type of organ transplant that you have had.

Complications, including graft-versus-host disease, in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with ZYNYZ. Your healthcare provider will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with ZYNYZ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with ZYNYZ if you have severe side effects.

Before you receive ZYNYZ, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • have received an organ transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. ZYNYZ can harm your unborn baby.
  • Females who are able to become pregnant:
    • Your healthcare provider should do a pregnancy test before you start treatment with ZYNYZ.
    • You should use an effective method of birth control during your treatment and for 4 months after your last dose of ZYNYZ. Talk to your healthcare provider about birth control methods that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ZYNYZ.
  • are breastfeeding or plan to breastfeed. It is not known if ZYNYZ passes into your breast milk. Do not breastfeed during treatment and for 4 months after your last dose of ZYNYZ.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of ZYNYZ include tiredness, muscle and bone pain, itching, diarrhea, rash, fever, nausea

These are not all the possible side effects of ZYNYZ. Call your doctor for medical advice about side effects.

General information about the safe and effective use of ZYNYZ.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. If you would like more information about ZYNYZ, talk with your healthcare provider. You can ask your healthcare provider for information about ZYNYZ that is written for health professionals.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Incyte Medical Information at 1-855-463-3463.

Please see the full Prescribing Information, including the Medication Guide, which includes a more complete discussion of the risks associated with ZYNYZ.

INDICATIONS AND USAGE

ZYNYZ is a prescription medicine used to treat a type of skin cancer called Merkel cell carcinoma in adults. ZYNYZ may be used to treat your skin cancer when it has spread or returned.

It is not known if ZYNYZ is safe and effective in children.

ZYNYZ is approved based on tumor response and duration of response. There are ongoing studies to confirm the clinical benefit of ZYNYZ.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ZYNYZ?

ZYNYZ is a medicine that may treat a certain type of skin cancer by working with your immune system. ZYNYZ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

Lung problems: cough, shortness of breath, chest pain

Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; severe stomach-area (abdomen) pain or tenderness

Liver problems: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); bleeding or bruising more easily than normal

Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, loss of appetite

Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes

Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with ZYNYZ. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include:

  • chest pain, irregular heartbeat, shortness of breath, or swelling of ankles
  • confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
  • double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
  • persistent or severe muscle pain or weakness, muscle cramps
  • low red blood cells, bruising

Infusion reactions that can sometimes be severe. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, back or neck pain

Rejection of a transplanted organ. Your healthcare provider should tell you what signs and symptoms you should report and monitor you, depending on the type of organ transplant that you have had.

Complications, including graft-versus-host disease, in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with ZYNYZ. Your healthcare provider will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with ZYNYZ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with ZYNYZ if you have severe side effects.

Before you receive ZYNYZ, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • have received an organ transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. ZYNYZ can harm your unborn baby.
  • Females who are able to become pregnant:
    • Your healthcare provider should do a pregnancy test before you start treatment with ZYNYZ.
    • You should use an effective method of birth control during your treatment and for 4 months after your last dose of ZYNYZ. Talk to your healthcare provider about birth control methods that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ZYNYZ.
  • are breastfeeding or plan to breastfeed. It is not known if ZYNYZ passes into your breast milk. Do not breastfeed during treatment and for 4 months after your last dose of ZYNYZ.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of ZYNYZ include tiredness, muscle and bone pain, itching, diarrhea, rash, fever, nausea

These are not all the possible side effects of ZYNYZ. Call your doctor for medical advice about side effects.

General information about the safe and effective use of ZYNYZ.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. If you would like more information about ZYNYZ, talk with your healthcare provider. You can ask your healthcare provider for information about ZYNYZ that is written for health professionals.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Incyte Medical Information at 1-855-463-3463.

Please see the full Prescribing Information, including the Medication Guide, which includes a more complete discussion of the risks associated with ZYNYZ.